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PATHOGENS AND INFECTIOUS DISEASES: WEST NILE VIRUS

December 29th, 2010

Formerly found primarily in the temperate regions of Europe and North America, West Nile virus (WNV) has presented a threat to public health, equine health, and at least since 1999 in the United States, to the health of human and bird populations. Prior to August 1999, West Nile virus had never been reported in the United States. However, in 1999, thousands of crows and other birds in the eastern United States began to die of a disease that looked remarkably like WNV and was labeled “West Nile-like virus.” Subsequent testing confirmed that the virus is actually the authentic WNV, and the look-alike designation has been dropped. As crows and birds started dying from WNV, humans began to become sick. In 1999, 62 cases of severe disease, including 7 deaths, occurred in the New York area.
Dogs, cats, other species of birds, and horses have been diagnosed with the virus to date. How does one get infected? What are the symptoms of West Nile virus? What, if anything, can you do to protect yourself?

Transmission
Animals, birds, and humans are all infected with WNV by the same culprit: a mosquito bite, primarily one of the Culex species that is infected with the West Nile virus. The basic transmission cycle starts with mosquitoes, who feed on infected birds. The virus then circulates in their blood for a few days. After an incubation period of 10 days to 2 weeks, infected mosquitoes can then transmit West Nile virus to humans and animals as they bite to take blood. The virus is located in the mosquito’s salivary glands, and when the insect takes a blood meal, the virus is injected into the animal, bird, or human, where it may multiply and cause illness.

Symptoms
For the most part, symptoms are mild and include fever, headache, and body aches, often with skin rash and swollen lymph glands. Some patients, however, develop a form of encephalitis, or inflammation of the brain, that may include symptoms of high fever, neck stiffness, stupor, disorientation, coma, tremors, convulsions, muscle weakness, paralysis, and on rare occasions, death.

Treatment
There is no specific therapy for the disease. For severe symptoms, hospitalization with IV fluids, breathing management and respiratory support, and prevention of secondary infections are typically provided. There is no vaccine and no specific antiviral medication.

Prevention
Since mosquito bites are the primary threat to humans, precautions designed to protect against such bites are recommended. Wearing protective clothing and using insecticides with DEET are the norm, as well as avoiding being outdoors at dawn, dusk, and early evening, when mosquitoes are most active.
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FIRST STAGE OF STRESS BREAKDOWN: EXCESSIVE USE OF STIMULANTS, PHYSICAL ILLNESS, FEVER

December 19th, 2010

Excessive use of stimulants
Another common cause of feelings of agitation is the consumption of excessive amounts of tea,   coffee and cola drinks containing caffeine. The caffeine and other drugs in these stimulant drinks cause stimulation by release of noradrenalin in the body. Excessive amounts of stimulants can produce a state indistinguishable from severe anxiety.
A similar comment applies as with sedative withdrawal. Excessive use of stimulants is not in itself a primary cause of stress breakdown. However, a person taking on too many worries and problems, feeling tired and worn, might well begin drinking extra cups of tea and coffee. The agitation produced by the excess caffeine might be indistinguishable from anxiety due to nervous system overload. A person seeking to use the anxiety equation to self-diagnose anxiety needs to be aware of this fact.

Physical illness, fever
When a person is coming down with a physical illness, the brain’s processing abilities may be impaired and stress breakdown may occur at lower levels of stress than would be otherwise tolerated. The illness need not be a condition primarily affecting brain function, such as meningitis or encephalitis. Many different disorders may cause relative failure of the brain’s processing capacity.
Fever due to any cause can so embarrass brain function as to produce delirium at times. When the onset of such an illness is gradual, the first sign of being ill may well be the sudden onset of anxiety symptoms in response to a normal workload.
It is not uncommon to find multiple factors involved in abnormal physiological states lowering the brain’s ability to handle incoming information adequately. Many of us are too fat and too unfit; we smoke, we drink alcohol and abuse stimulant drugs such as caffeine, we eat the wrong foods at the wrong times, we have irregular sleeping hours and often don’t relax. We often start the working day having already so disadvantaged our nervous systems that we have little hope of avoiding some level of stress breakdown.

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ASTMA IN CHILDREN: WHAT GOES WRONG ?

December 11th, 2010

WHAT GOES WRONG in the asthmatic lungs? First, let us look at the walls of the bronchial tube. These walls are made up of various cells, muscle tissue, and mucus-secreting glands. In a normal lung, air moves in and out of these bronchial tubes freely, and the air exchange in the alveoli maintains a perfect balance of oxygen and carbon dioxide throughout the entire body.
In a person suffering from asthma, the bronchial tubes become swollen and narrow. Hundreds of thousands of cells in the walls of the bronchial tubes, called mast cells, (discussed later in the chapter) secrete toxic chemicals, called mediators. These chemicals cause the walls of the bronchial tubes to swell up, and the bronchial muscles go into a spasm. The result is a swollen, inflamed, obstructed bronchial tube that blocks the passage of air in and out of the lungs.
When air moves in and out of these obstructed and inflamed tubes, typical symptoms of asthma—coughing and wheezing—occur. Since the bronchial tube is constricted or narrow, the flow of air is obstructed, and the air passing through the narrow obstructed passage produces a hissing or a wheezing sound.
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HOW A MEMORY CLINIC WORKS

September 22nd, 2010

To show how a memory clinic works on a practical level (and in case someone you know is referred to one so that you know what to expect), I have set out below how the clinic at the Royal London Hospital (Mile End) functions, based on their own printed scheme.
• Referrals should be discussed on Wednesday morning with regards to suitability for the memory clinic or day hospital. When necessary a domiciliary visit should be carried out.
•     Appointments will be dealt with by X. Transport will be arranged if necessary.
•     Where necessary notes should be requested from other agencies, i.e. hospitals, social services, GPs and community psychiatric nurses. If there is very little information about the patient, then check with the geriatric office in case any more details are forthcoming.
•     Wednesday, prior to the memory clinic, X should check that we have all the notes for the clients coming to the clinic and those for review.
•     On Thursday:
9.00 am clients arrive.
9.15 am will be seen by the doctors and the rest of the team.
1.00 pm team meets to discuss client and formulate plan.
•     Plan is then explained to client and relatives. Immediately afterwards the team will meet to discuss the review cases and appoint a key worker who will ensure that all services have been arranged. They will also telephone or contact the client or relatives two months after the review to check that services have happened and that no new problems have arisen and report back to the team.
•     After the clinic X will keep a record on the clients who have attended and those who have been reviewed.
•     The doctor will write to all the services involved on behalf of the team.
•     During the memory clinic the roles are:
Nurses will fill in as many details of history (family and medical) as possible. They will give the health education booklet out and discuss with client and carers any worries they may have, explaining conditions if necessary.
Doctors will do the mini-mental assessment, full physical and blood tests and talk to the relatives.
Social worker will talk to relatives regarding social aspects and explain about the relatives’ support group.
Occupational therapist assesses client’s ADL (activities of daily living).
• Computer memory testing will be done by a member of the team. Domiciliary visits will be done by one or two members of the team, either before or after the memory clinic visit.
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INFLUENZA

September 22nd, 2010

As with the common cold there is no cure for influenza. A vaccine does exist. This product is an attempt to second guess which strains of influenza virus will occur each coming winter.
Antibiotics don’t work and should not be routinely prescribed in the treatment of influenza. Some experts argue that it is better to catch the flu than have the vaccine. Infection with a free range variety of the virus is thought to provide a better immunity.
The flu virus mutates annually; but severe epidemics seem to occur in patterns of seven to ten years. A bad year of flu usually means a few ensuing years of grace because the population has built up significant levels of resistance. The flu epidemic of 1918 killed twenty million people in different countries around the world and there is no reason why such a ferocious epidemic could not occur again.
Home Remedies
In every society there are a group of people who claim never to have suffered a cold or a bout of influenza in their lives. Either these people are endowed with super immune systems or they keep their immunity in top shape by the way they lead their lives. Habits supporting the immune system include the maintenance of a happy family, avoidance of stressful circumstances, good nutrition, healthy sleeping habits and regular levels of modest exercise.
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BEATING THE BLOOD PRESSURE BLUES FOR A HEALTHY HEART: WHO GETS HYPERTENSION?

June 2nd, 2010

As mentioned earlier, nearly 60 million men and women in the United States have hypertension. That makes it that country’s most common chronic illness. No one is totally immune, though some are more likely than others to develop hypertension.
In nine out of ten cases, no particular cause can be determined. The condition for such patients is termed primary hypertension. If elevated blood pressure results from another cause, such as kidney disease and disorders of the blood vessels, the ailment is called secondary hypertension. Occasionally the underlying cause of secondary hyper-tension can be eliminated by surgery or medical treatment. But for primary hypertension there is no cure. On the other hand, we can very effectively control it such that the condition poses no health risks.
Certain factors may predispose individuals to develop hypertension. Those with a family history are more likely to develop it than those without this genetic background. At least 50 per cent of those with high blood pressure have one or more parents with the condition.
While hypertension can develop early in life, sometimes even in childhood, most patients see their blood pressure rise between the ages of 35 and 50. By the age of 64, more than half the population has an elevated pressure.
Normally we think of hypertension as a man’s problem, but that’s true only until age 50. After that, women catch up and by age 60 more women than men have high blood pressure. For both men and women, this is a major risk factor in heart disease, though death caused by complications from hypertension such as stroke is more frequent in men.
Race plays an important role. Regardless of age, blacks have twice the incidence of hypertension. In fact, blacks develop the condition much younger than do whites, and for them it is the leading cause of death. Apparently both genetics and environment are involved. Black dietary preferences have been implicated, and blacks have been shown to retain sodium more readily than do whites. For blacks, salt and sodium restriction is mandatory in almost all cases.
Nearly four out of ten overweight persons have hypertension. Conversely, those who lose weight show a significant decrease in blood pressure. As we’ll see, that becomes a necessary part of hypertension treatment.
About 70 per cent of patients with high blood pressure are in the “mild hypertension” category. Twenty per cent fall into the moderate classification, and about ten per cent have severe hypertension.
Your doctor may have told you that you have labile hypertension. This means that your blood pressure is sometimes but not always high, and it might reflect a stressful situation. Some patients, about 10 to 25 per cent, progress from labile hypertension to mild hypertension.
Other patients, including me on occasion, will have what’s known as white coat hypertension. This means our blood pressure goes up in the doctor’s office during examinations, but would otherwise be normal. In my case, I often react to doctor’s examination in the same way as I would to a test in school or an athletic competition. After a few minutes of conversation and relaxation the pressure drops to normal.
There is a rare type of high blood pressure that requires intensive treatment to prevent severe damage to the body’s organs and even death. This is called accelerated or malignant hypertension. In such cases, which have nothing to do with cancer, diastolic pressure goes to 130 and beyond, with systolic pressure above 200. This severe form of hypertension quickly gets worse and calls for emergency measures to bring it under control.
Regardless of your blood pressure measurement, your doctor will keep close watch on it, testing during every visit. We can’t do much about risk factors affecting our cardiovascular health such as genetics, age, or sex. But hypertension is something we can alter. Since 1972, when doctors started to get serious about blood pressure, the mortality rate due to strokes has dropped 50 per cent. That’s impressive. And there’s no reason you shouldn’t succeed in controlling your own blood pressure and thus eliminating a major heart disease risk factor.
Again, there are no symptoms. Yes, stress can result in an increase in blood pressure, but only temporarily. The only way you can tell how you’re doing is by close monitoring. You might even want to invest in home equipment. You’ll find a wide variety available, including some very easy to use devices which show your measurement in a digital readout. Talk with your doctor about whether this would be a good idea for you and, if so, which type would be best for your needs.
There is no cure for primary hypertension. But methods of control can be so effective that the condition need not be a concern. The important thing is to make the commitment to that control.
The treatment you and your doctor decide upon for your blood pressure control will depend on the severity of hypertension and your willingness to make some lifestyle modifications. In some cases, prescription drugs will be absolutely necessary, at least at the beginning to quickly reduce your health risks. If you, like most patients, have a mild hypertension, lifestyle modifications alone may be enough for control.
It’s wrong to think that just swallowing a few pills is an effective method of control. First, lifestyle changes will make the drugs more effective. Second, you can get by with fewer drugs, and possibly none at all, with some modifications. That’s important, since antihypertensive drugs may involve some side effects, and few patients want to take more medicine than they absolutely have to.
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Cardio & Blood/ Cholesterol

BEATING THE BLOOD PRESSURE BLUES FOR A HEALTHY HEART: THE INVISIBLE NEMESIS

June 2nd, 2010

How’s your blood pressure today? Unless you had it checked, you can’t be sure. That’s because there are no symptoms of high blood pressure, also known as hypertension. But we do know that it’s one of the Big Three risk factors in heart disease along with cigarette smoking and elevated cholesterol levels, and it’s the Number One risk factor for strokes. We also know that we can completely control blood pressure in almost every case.
You’re not alone. It’s estimated that nearly 60 million men and women in the United States have an elevated pressure. To a large extent the condition is another part of your genetic heritage, and your blood pressure has probably been slowly but surely increasing since you were much younger, perhaps even back to your childhood.
On its most basic level, blood pressure is quite easy to understand. It refers to the pressure required to pump blood from the heart through the arteries to all parts of the body. Through a complex system of checks and balances, blood pressure is regulated and adjusted. During exercise pressures goes up, and at rest it comes back down. Different pressures may be needed in different parts of the body at different times.
Blood pressure is something we just don’t think much about since we can’t feel it. Even when one is completely calm and relaxed, blood pressure may be elevated. Over a period of time, hypertension leads to a thickening or hardening of the arteries, which ate also weakened in the process.
There are two important blood pressure measurements. The first is the systolic pressure, the pressure of the blood pushing against the artery wall as the heart beats. The second is the diastolic pressure, a measurement between beats when the heart tests. A reading of 120/80 is stated as “120 over 80″ with the systolic being 120 and the diastolic 80. That reading, by the way, is completely normal, and the patient would be termed normotensive.
For years there was controversy as to what would be considered high blood pressure. Then in 1972 the US National High Blood Pressure Education Program was launched by the US National Heart, Lung, and Blood Institute in conjunction with the nation’s major medical organisations. This program has initiated efforts to educate both patients and physicians as to the seriousness of hypertension and methods of controlling it. Today there is virtual consensus as to the classification of blood pressure in adults 18 years or older.
The risk of cardiovascular problems related to blood pressure increases with greater levels of both systolic and diastolic pressure. Diastolic pressure is normally of greatest concern, but systolic pressure is also considered. You’ll note in the following breakdown that the term “mild hypertension” is used. That’s somewhat deceptive and should not be construed to mean that such an elevation is of no consequence. All elevations of blood pressure should be treated and controlled.
You’ve had your blood pressure measured many times, but you may not know exactly how the measurement is made. The apparatus used is called a sphygmomanometer (“sfig-mo-ma-na-meh-ter”). It consists of a cloth or rubber cuff to wrap around the arm, a rubber air bulb to pump air into the cuff, and a manometer, which measures pressure in millimetres of mercury in a glass tube similar to a thermometer. As air enters the cuff, mercury rises in the manometer. The cuff temporarily cuts off blood flow in the forearm.
As air is gradually let out of the cuff, blood begins to flow again and the mercury in the glass tube drops. The doctor or nurse (or other trained person) listens to the blood flow through a stethoscope placed on the artery just below the cuff. One first hears a thudding or tapping sound as the blood spurts out. It occurs when the air pressure in the cuff is a bit lower than the pressure in the artery. The reading on the glass tube at the time of that first sound is your systolic pressure.
Mercury continues to fall as more air is released from the cuff. When the tapping sound stops, blood is smoothly flowing between heartbeats. The moment the sound stops a reading is taken from the manometer tube. This is your diastolic pressure.
Your blood pressure varies from day to day, situation to situation, and even minute to minute. That’s why to get an accurate assessment the doctor will take two, three or even more readings. He may also take both sitting and standing pressures. And to be absolutely certain of your condition, at least two examinations on different days are needed.
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Cardio & Blood/ Cholesterol

COMMON INFECIONS OF CHILDHOOD: STRIDOR (CROUP)

May 21st, 2009

Stridor is an inspiratory noise (heard when the child is breathing in) which has been described as sounding like the bark of a seal. It generally indicates some obstruction or narrowing of the windpipe (trachea). The most common cause is croup, which is relatively common in young toddlers, and which is caused by a viral infection. However, stridor is occasionally caused by a condition called epiglottitis, which is due to a germ and which is serious and potentially life threatening (and for which immunisation is now available). It may also be caused by an inhaled foreign body.

Croup

Croup is very common in young children. It is usually associated with a cold (and is therefore more common in winter), and for the most part is not a serious condition. However, the obstruction to the breathing tube is occasionally severe enough to cause breathing difficulties, and the child needs urgent medical attention and sometimes observation and treatment in hospital.

Cause

The stridor or croup that is heard when the child breathes in is caused by swelling of the breathing tube just below the vocal cords. This is caused by one of the viruses that are responsible for the common cold.

Clinical features

The child usually has symptoms of a cold before the onset of croup, including a runny nose, sore throat, fever, and irritability. He then develops a harsh, barking cough, sometimes a hoarse voice, and then noisy breathing. The noise is heard when he breathes in (in contrast to asthma, in which the wheeze occurs as the child breathes out).

The stridor and the cough are usually worse at night and when the child is distressed. In the majority of children, the symptoms improve over a few days and then disappear. In a small number of children the croup is more severe and the child has difficulty with breathing. Sometimes there will be drawing in of the child’s breastbone and the muscles between the ribs, as well as flaring of the nostrils. He may appear restless and have trouble feeding and drinking, and will not want to lie down. Severe croup requires emergency medical attention.

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COMPLICATIONS OF PREGNANCY: RHESUS INCOMPATIBILITY

May 19th, 2009

This is a situation in which a newborn’s red blood cells are destroyed because the mother’s and the baby’s blood groups are incompatible. During pregnancy and mainly during delivery some red blood cells from the foetus cross the placenta and enter the mother’s bloodstream. If the mother is Rhesus negative and the foetus is Rhesus positive, the mother will produce antibodies (immunity) which recognise the foetal red blood cells as foreign. During a first pregnancy there is little chance that this will become a problem. However, in a subsequent pregnancy the mother’s immune response is more vigorous and her antibodies cross the placenta and attack the foetus red blood cells. This can lead to problems of anaemia and oedema (fluid overload) while the baby is still in the womb, and to severe jaundice of the baby after birth (due to the release of a substance called bilirubin from the damaged red blood cells).

To prevent problems resulting from Rheus incompatibility, Rheus negative mothers are given a substance called anti-D immediately after delivery. This destroys any Rhesus positive cells from the foetus which are present in the mother’s bloodstream, preventing the mother from mounting an immune response. Because antibodies do not develop a subsequent pregnancy is problem free.

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YOUR MARITAL HEALTH/THE MOST OFTEN ASKED QUESTION: WHY CAN’T WE COME TOGETHER?

May 18th, 2009

“Why can’t we come together? We have tried every trick in the book. We never climax together.”

ANSWER: Nobody ever comes together if by that you mean simultaneous pelvic muscle contraction. If it does happen, it is rare and an accident, mere chance and luck. The effort to accomplish this mutual reflex would be like trying to sneeze together. You might be able to do it, but you would wait a long time, and even if you did it, you would wonder why. Trying to have pelvic contractions together only gets in the way of enjoying psychasms together, which is much more satisfying because they are much longer and easier to share. Remember that orgasmic contractions last less than fifteen seconds. It makes little sense to spend most of the sexual encounter to synchronize your fifteen seconds. A super marital sex rule is that where you are going together is much more important than trying to end together. It’s too bad the-word “climax” was ever used. A better word might be to ‘ ‘preamble” together, to start instead of end. You might try using a less motion-oriented vocabulary of “come,” “get,” and “do” in favor of the more experiential terms of “share,” “feel,” and “be.”

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